Endocrine Abstracts

Background: Regular physical exercise during childhood and adolescence can promote growth and development of muscle and bone mass. Although physical exercise is closely linked to the anabolic function of the GH /IGF-I axis the real impact of resistance training on GH/IGF axis is still unclear. The kinetics of IGF-I and IGFBP-3 during chronic training is not fully understood yet and an initial catabolic phase followed by an later anabolic phase has been reported in swimmers.</p...

Background: The GH-IGF system plays an important role in strength gain. Some studies suggest that Zinc, Magnesium and Pyridoxine (ZMA) supplementation could increase GH/IGF and testosterone levels in young subjects. This hypothetical increase could lead to significant changes in body composition. ZMA is a very popular supplement, easily found in specialty stores, and it is presumed to increase GH, IGF-I and testosterone levels. However, studies are divergent regarding its effi...

The hypoxia, associated to intra-uterine growth restriction, is related to high concentrations of IGFBP1 and unchanged concentrations of IGF1 in animals. Nevertheless, during threatening life events, low IGFI concentrations and high IGFBP1 concentrations was reported. Furthermore, severe hypoxia increased the IGF1R expression of the neuronal growth cones in the ovine fetal brain. No information is available regarding the regulation of the IGF system by the acute hypoxia in hum...